How much does a Tissue pathology exam cost?

Tissue pathology exam (biopsy) · CPT 88305 · A tissue pathology exam is the microscopic analysis of a biopsy sample to diagnose disease such as cancer.

The typical insurer-negotiated price for a Tissue pathology exam (biopsy) is about $116, with most between $73 and $194 ($208 cash/self-pay). Based on published rates from 3,158 U.S. hospitals. Hospital list charges run about $352 — roughly 3× higher.

Insurer-negotiated
$116
typical · $73$194
Cash / self-pay
$208
typical cash price
Hospital list charge
$352
3× the negotiated rate

Source: medians across 3,158hospitals' machine-readable price files (required by federal law since 2021). Figures are estimates and vary by hospital, region, insurer, and plan.

Tissue pathology exam (biopsy) cost — frequently asked questions

How much does a Tissue pathology exam (biopsy) cost with insurance?

The typical insurer-negotiated rate for a Tissue pathology exam (biopsy) is about $116, with most falling between $73 and $194, based on published rates from 3,158 U.S. hospitals. What you actually pay depends on your plan's deductible and coinsurance.

How much does a Tissue pathology exam (biopsy) cost without insurance?

Cash or self-pay prices for a Tissue pathology exam (biopsy) run around $208. Uninsured patients are often billed the much higher hospital "list" charge first (about $352), so it's worth asking for the cash or self-pay rate and negotiating.

Why is my hospital Tissue pathology exam (biopsy) bill so much higher?

Hospital "list" (chargemaster) prices for a Tissue pathology exam (biopsy) run about $352 — roughly 3× the $116 insurers actually pay. The list price is a starting point almost no one pays; the negotiated and cash rates are the realistic benchmark.

Can I negotiate the cost of a Tissue pathology exam (biopsy)?

Yes. If you were charged well above the typical negotiated rate (about $116), that gap is negotiable. Upfronte audits your bill against real hospital pricing data and can negotiate it down on your behalf — no savings, no fee.

Were you charged more than $116?

Upload your bill and Upfronte will check it against real hospital pricing data and negotiate overcharges. No savings, no fee.

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Tissue pathology exam (biopsy) cost by location

Median negotiated prices for specific states and metro areas.

Metro areas

States

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